中文简介
分子识别杂志(JMR)出版了原始的研究论文和评论，描述了我们在理解生命科学中的分子识别现象方面的重大进展，涵盖了生物化学、分子生物学、医学和生物物理学的所有方面。研究可采用实验、理论和/或计算方法。该杂志的重点是涉及生物分子及其生物/生化伙伴的识别现象，而不是对金属离子或无机化合物的识别。分子识别包括两个或多个生物分子、分子集合体、细胞模块或细胞器之间的非共价特异性相互作用，如受体配体、抗原抗体、核酸蛋白、糖凝集素等。该杂志邀请的手稿，旨在实现一个完整的描述分子识别机制之间的结构，动力学和生物活性方面的特征良好的生物分子。这些研究可能有助于未来新药和疫苗的开发，尽管对新药和疫苗的实验测试不在该杂志的范围之内。描述设计或建模新分子实体或描述生物分子间相互作用的标准方法和技术的应用的手稿，但不提供对分子识别过程的新见解，将不予考虑。同样，涉及未在序列水平上进行特征描述的生物分子的手稿(例如小牛胸腺DNA)将不予考虑。典型的技术包括拓扑模拟的合成、位点定向突变或分子印迹，以及定量测量分子相互作用的生物物理方法。AFM、光学镊子、SPR、生物传感器和微热量测量等特定方法，以及NMR、MRI、MS、GC、LC、HPLC、PET和结晶学等一系列分析方法，可以用来建立分子识别过程的机理、动力学和力。理论和计算方法有助于分子识别过程的建模、预测、仿真和设计。在分子水平上的力学理解可以借助于计算方法，如分子静电分析、分子动力学模拟和自由能计算。
英文简介
Journal of Molecular Recognition (JMR) publishes original research papers and reviews describing substantial advances in our understanding of molecular recognition phenomena in life sciences, covering all aspects from biochemistry, molecular biology, medicine, and biophysics. The research may employ experimental, theoretical and/or computational approaches.The focus of the journal is on recognition phenomena involving biomolecules and their biological / biochemical partners rather than on the recognition of metal ions or inorganic compounds. Molecular recognition involves non-covalent specific interactions between two or more biological molecules, molecular aggregates, cellular modules or organelles, as exemplified by receptor-ligand, antigen-antibody, nucleic acid-protein, sugar-lectin, to mention just a few of the possible interactions. The journal invites manuscripts that aim to achieve a complete description of molecular recognition mechanisms between well-characterized biomolecules in terms of structure, dynamics and biological activity. Such studies may help the future development of new drugs and vaccines, although the experimental testing of new drugs and vaccines falls outside the scope of the journal. Manuscripts that describe the application of standard approaches and techniques to design or model new molecular entities or to describe interactions between biomolecules, but do not provide new insights into molecular recognition processes will not be considered. Similarly, manuscripts involving biomolecules uncharacterized at the sequence level (e.g. calf thymus DNA) will not be considered.Typical techniques would include synthesis of topological mimics, site directed mutagenesis or molecular imprinting, together with biophysical methods for the quantitative measurement of molecular interactions. Specific methods such as AFM, Optical Tweezers, SPR, Biosensors and Microcalorimetry, and the range of analytical methods such as NMR, MRI, MS, GC, LC, HPLC, PET, and Crystallography may be used to establish the mechanisms, dynamics and forces of molecular recognition processes. Theoretical and Computational Methods aid the modeling, prediction, simulation and design of molecular recognition processes. Mechanistic understanding at a molecular level can be aided by computational approaches such as molecular electrostatic analysis, molecular dynamics simulations and free energy calculations.
近年期刊影响因子趋势图
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